Moderate Negative Relationship Research Articles

Knowledge, Attitude, and Dispensing Practice of Emergency Contraceptive Pills among Community Pharmacists: A Cross-sectional Survey

Background: The improper or incorrect usage of birth control results in unintended pregnancy. In India, 78% of pregnancies are accidental, with unwanted pregnancies accounting for about 25% of all pregnancies. The family, society, and country may all be financially impacted by such pregnancies. Community pharmacists must have a good attitude and sufficient knowledge of emergency contraception pills (ECPs) in order for women to receive them in a timely manner and as a result, have fewer unintended pregnancies. The purpose of this study is to investigate the knowledge, attitude, and, practices of community pharmacy practitioners towards ECPs. Methods: A cross-sectional study was carried out on retail pharmacies located in Madhya Pradesh, Mumbai. A standardized questionnaire was used in 164 community pharmacies to interview about CPPs using a convenience sampling technique. The survey evaluated the CPP's dispensing procedures, knowledge, attitude, and demographic profile. Data analysis was carried out by using the statistical package for the social sciences (SPSS) version 18 (SPSS Inc., Chicago, IL, USA). Results: A total of 164 registered pharmacists participated in the study, which included 76.1 % (n=124) males and 23.9% (n=39) females. Among all the participants, 73.0% of them had a diploma in pharmacy (D Pharm) education, and half of the study participants had a working experience between 1-5 years. In this study, 56.64 %, 27.6%, and 16% of participants had average knowledge, sound knowledge, and poor knowledge, respectively. Results showed that 90.2% (147) of pharmacists came under the positive attitude category, 5.5% of pharmacists had a negative attitude, and 4.3% had a neutral attitude. A moderate positive linear relationship (0.401) existed between the knowledge and attitude of the pharmacist in this study. Attitude and dispensing of emergency OC as OTC to people older than 18 years old and less than 18 years old showed a moderate negative linear relationship. After adjusting the possible confounder variables, age and years of experience significantly affected the knowledge, attitude, and practice of EC. Conclusion: In conclusion, the present study has shown that there is generally a lack of knowledge and poor attitude toward emergency contraceptive medicines among community pharmacists. Therefore, it is recommended that improving pharmacist's knowledge, attitude, and practice (KAP) through proper training and counseling about EC can enhance the appropriate use of drugs.

Is there a relationship between somatosensory impairment and the perception of pain in stroke survivors? An exploratory study.

Pain and somatosensory impairments are commonly reported following stroke. This study investigated the relationship between somatosensory impairments (touch detection, touch discrimination and proprioceptive discrimination) and the reported presence and perception of any bodily pain in stroke survivors. Stroke survivors with somatosensory impairment (N = 45) completed the Weinstein Enhanced Sensory Test (WEST), Tactile Discrimination Test, and Wrist Position Sense Test for quantification of somatosensation in both hands and the McGill Pain Questionnaire, visual analog scale and the Neuropathic Pain Symptom Inventory (NPSI) for reporting presence and perception of pain. No relationship was observed between somatosensory impairment (affected contralesional hand) of touch detection, discriminative touch or proprioceptive discrimination with the presence or perception of pain. However, a weak to moderate negative relationship between touch detection in the affected hand (WEST) and perception of pain intensity (NPSI) was found, suggesting that stroke survivors with milder somatosensory impairment of touch detection, rather than severe loss, are likely to experience higher pain intensity [rho = -0.35; 95% confidence interval (CI), -0.60 to -0.03; P = 0.03]. Further, a moderate, negative relationship was found specifically with evoked pain (NPSI) and touch detection in the affected hand (rho = -0.43; 95% CI, -0.72 to -0.02; P = 0.03). In summary, our findings indicate a weak to moderate, albeit still uncertain, association, which prevents making a definitive conclusion. Nevertheless, our findings contribute to our understanding of the complexities surrounding the experience of pain in survivors of stroke and provide direction for future studies.

DISTRIBUTION PATTERN OF TOTAL SUSPENDED SOLIDS (TSS) IN KAMPAR RIVER ESTUARY, PELALAWAN REGENCY, RIAU PROVINCE

The Kampar River Estuary is the main river in Riau province, which empties into the Malacca Strait and has a unique potential for research. The characteristics of the Kampar River Estuary are concurrent and have high tidal elevations, resulting in the occurrence of a Tidal Bore, which is referred to as Bono. The impact of sedimentation is generally quite detrimental, namely the siltation in several places, such as the waters of the Kampar River Estuary, which are dense areas of human activity. This study aimed to determine the relationship between hydrodynamic patterns, suspended solids' distribution pattern, and the concentration value of suspended solids distribution in the Kampar River estuary. This research method is surveyed and discussed descriptively. Current patterns affect the distribution of sediments in the Kampar River estuary. The TSS distribution pattern tends to follow the same direction as the movement of tidal currents where, during high tide, it tends to lead to the southwest of the Kampar River estuary, while during low tide tends to lead to the northeast and northwest, it this is because, in the Kampar River estuary, there is an island that makes the mouth of the Kampar River estuary V-shaped. Between hydrodynamic patterns and TSS distribution patterns, there is a moderate negative relationship (r = 0.50), which means that there is a significant influence between hydro patterns and TSS distribution patterns in the waters of the Kampar River estuary, between hydrodynamic patterns and TSS distribution patterns in the waters of the Kampar River estuary. The lowest value of TSS concentration in the waters of the Kampar River Estuary at high tide to low tide is Station 7, with a range of 102 mg/L, and the highest value at Stations 3, 4, and 9. At station 3, there are values ranging from 1756 mg/L; at station 4, there are values ranging from 2823 mg/L; and at station 9, there are values ranging from 1269 mg/L; the high concentration of TSS results in low brightness in the study area.

Comparative analysis of employees' work engagement and fanaticism behavior with turnover intention

This study aims to examine the relationship between individuals exhibiting a positive attitude related to work, the work with emotional, physical, and mental presence in advanced interaction, it also aims to analyze the relationship between revealing the positive energy related to the work, showing a high sensitivity to the their job and the integration with that defined as work engagement and fanaticism with the working conditions of employees they showed as a conscious decision orientation on turnover intention of the organization if they are unsatisfied. With this aim, an empirical study was conducted on 347 employees working in private bank branches, in the southeast region of Turkey. After data handling, they were used for analysis. The results of the study indicated that, according to gender, there is a significant relationship between gender and intention to leave the job in favor of men, the intention to leave a job for men was significantly lower than for women, according to educational status, the devotional work behavior of graduate higher than university. In addition, there is a moderate negative relationship between devotional work behavior and the intention to leave the job.

The Cake is Not a Lie: An Exploration of the Gamer Culture, Coping Methods, and Resiliency

ABSTRACT This study explored dynamics that would be beneficial to the counseling community in understanding gamers as a unique culture. In addition to descriptive variables that served the purpose of better understanding the culture and controlling for any extraneous influences, the focus was on gamer personality and motivation, coping strategies and resiliency. The potential relationship between gamer personality types and coping strategies were explored through comparisons of personality type and resiliency variables, along with an assessment of whether a person’s preferred coping methods mediated any relationship between personality and resiliency. Except for a moderate negative relationship between engagement style coping and resiliency, there was no significant relationship between personality type, coping strategy, and resiliency. However, as an exploratory study, interesting findings related to demographic variables were uncovered.

Initial Psychometric Properties of the Catalight Family Wellbeing Scale.

Wellbeing refers to a person's overall happiness and satisfaction with life. Wellbeing for people with Intellectual and Developmental Disabilities (I/DD) and their families is historically significantly lower compared to the general population. It is important in the context of behavioral health treatment to not only measure the individual who is receiving treatment's overall wellbeing, but also the wellbeing of the family. The purpose of this study was to understand the initial psychometric properties of the Catalight Family Wellbeing Scale. The Catalight Family Wellbeing Scale was developed for families who have a child with I/DD. Caregivers of 3106 families who have a child with a diagnosed I/DD, including autism spectrum disorder, completed the scale as part of their onboarding for behavioral health treatment along with three other questionnaires. The psychometric properties including internal reliability and factor structure were completed as well as initial convergent and divergent validity. Results of the analyses revealed very strong internal reliability and a three-factor structure. Validity analyses revealed a moderate positive relationship with parental self-efficacy and a moderate negative relationship with parental stress. Additionally, the sample population represents an ethnically diverse group with multiple co-occurring diagnosis in addition to I/DD. The initial psychometric properties of the Catalight Family Wellbeing Scale are positive and support the use of the scale for families who have a child with I/DD across a diverse sample.

The relationship between personality, self-compassion, and social interest levels of psychological counsellor candidates

ABSTRACT A cross-sectional research design was used to examine the relationship between personality, self-compassion and social interest levels of 351 psychological counsellor candidates. Data were collected with the Personality Test of Adjectives, the Self-Compassion Scale Short Form, and the Social Interest Index. Correlation and regression analyses were used to analyze data. A moderately negative relationship was found between self-compassion and neuroticism, while a moderately positive relationship was found between extraversion, openness to experience, and conscientiousness, and a low-level positive relationship was found between agreeableness. While a moderate negative relationship was observed between social interest and neuroticism, a moderate positive relationship was found between extraversion, openness to experience, agreeableness, and responsibility. Personality explained 47.6% of the variance regarding self-compassion and 42.2% of the variance regarding social interest.

Investigation of the Relationship Between Coping With the Disease and Affecting Cognitive, Physical, and Psychosocial Factors in People with Multiple Sclerosis.

To investigate the relationship between coping mechanisms in people with multiple sclerosis (MS, pwMS) and cognitive, physical, and psychosocial factors such as socio-demographic characteristics, disability, personality, stigma, quality of life, depression, and anxiety. One hundred and two pwMS were enrolled in this cross-sectional study. Demographics and clinical characteristics were recorded. Coping with the MS Scale (CMSS), including seven subscales, which are problem-solving, physical assistance, acceptance, avoidance, personal health control, energy conservation, and emotional release, was used to measure coping. Anxiety and depression levels, stigma, neuropsychological symptoms, and personality were measured by the Hospital Anxiety and Depression Scale (HAD), EuroQol-5D Quality of Life Scale (EQ-5D), Quality of Life in Neurological Diseases (NeuroQoL) -Stigma Scale, Multiple Sclerosis Neuropsychological Questionnaire (MSNQ), and Revised Eysenck Personality Questionnaire-Abbreviated Form (EKA-GGK), respectively. There was a weak statistically significant positive correlation between the physical support subscale and age and the disease duration and a strong positive correlation with EDSS (r= .214, p= .035; r= .213, p= .036; r= .582, p≤ .0001, respectively). There was a moderate negative relationship between the physical support subscale and the EQ-5D mobility, self-care, pain, and health subscales (r= -.434, p= .000; r= -.482, p= .000; r= -.526, p≤ .001, respectively), a weak negative correlation with anxiety, and a strong negative relationship with usual activities (r= -.379, p≤ .001; r= -.243, p= .017; r= -.384, p≤ .001, respectively). It has been shown that coping with MS can be affected by cognitive, physical, and psychosocial factors.

Upwelling-driven biogenic silica accumulation in the Yangtze Sea, South China during Late Ordovician to Early Silurian time: A possible link with the global climatic transitions

Silica accumulation in the Yangtze Sea during the Ordovician–Silurian (O–S) transition appears to have coincided with global climatic fluctuations, widespread upwelling, and volcanism. There is a need to further evaluate their respective contributions to silica deposition and potential relationships among these factors. The current study selected siliceous deposits in the Wufeng and Longmaxi Formations from four sections spanning the inner to outer Yangtze Sea, South China, to gain a deeper understanding of the climatic and oceanographic evolution associated with silica enrichment. Al/(Al + Fe + Mn) values, the presence of radiolarians, and Si isotope values of samples recovered from the investigated shale successions offer compelling evidence that the silica is largely of biogenic origin with some terrigenous contributions. Further, various productivity and redox proxies suggest that biogenic silica (BSi) accumulated under conditions of enhanced marine productivity and anoxic bottom water conditions. Hg/TOC and Zr/Al2O3 profiles suggest intermittent volcanism during the BSi deposition in the Yangtze Sea. However, the lack of correlation between BSi and Hg/TOC values indicates that volcanic iron fertilization was not responsible for BSi accumulation. Instead, most BSi-rich samples are dominated by low MnEF × CoEF values (<0.5), consistent with BSi deposited in modern upwelling settings. Hydrographic reconstruction based on Mo–U covariation indicates a more open water setting in the outer Yangtze Sea, while the coeval inner Yangtze Sea was relatively restricted. Therefore, upwelling events appear to have been more vigorous in the outer Yangtze Sea. Published and new Chemical Index of Alteration (CIA), BSi, and MnEF × CoEF data for the Wufeng and Longmaxi Formations across the inner to outer Yangtze Sea demonstrate that temporal and spatial variations of BSi were controlled by climate-driven upwelling. In particular, cool-water upwelling contemporaneous with Hirnantian glaciation may have been responsible for the establishment of the cool-water fauna of the shallow-water Guanyinqiao Bed and enhanced silica deposition in deeper water. Moreover, a moderate negative relationship between compiled CIA and BSi contents suggests that enhanced upwelling driving BSi accumulation appears to have been favored during cooling events. Integrated analysis of BSi deposits of the Laurentia and Baltica continental margins further suggests that BSi accumulation on continental margins during the O–S transition was primarily influenced by global cooling. Therefore, we suggest that wind patterns or/and thermohaline circulation, influenced by climate fluctuations, induced widespread cold water upwelling events during the O–S transition. Moreover, elevated BSi production diluted accumulating OM resulting in the observed parabolic relationship of BSi and TOC.

Determination of Compassion and Compassion Fatigue in Intensive Care Nurses.

Compassion is defined as the sadness felt by a living thing or a person due to a negative situation. Compassion fatigue describes emotional, physical, social and spiritual exhaustion or a decrease in these feelings. The concept of compassion, which is at the center of nursing, may be related to compassion fatigue in nurses. The aims of the study were to determine the level of compassion fatigue and compassion among intensive care nurses and to examine the relationship between them. This study was conducted through descriptive research and cross-sectional survey. The population of the research consisted of intensive care nurses from two hospitals in Turkey. Since the universe is accessible, the sample selection method was not used (n = 182). Demographic data form, Compassion Fatigue sub-dimension of the Professional Quality of Life Scale and Compassion Scale were used in the study. The mean score of the nurses' compassion fatigue was 15.86 ± 7.22, and compassion was 72.21 ± 7.28. There was a moderate negative relationship between compassion and compassion fatigue (r = -.405). It was determined that the nurses' compassion was at a moderate level and their compassion fatigue was at a low level. It can be assumed that ICU nurses' compassion is at a medium level and their compassion fatigue is at a low level. It was established that as the compassion level of the nurses increased, the level of compassion fatigue decreased. Developing a sense of compassion in nurses working in intensive care units can reduce compassion fatigue.

Rizobactérias promotoras de crescimento de plantas isoladas de solos cultivados usando plantas Glycine max L. como isca

ABSTRACT: The current production of major crops, such as Glycine max L., has become increasingly adept on the use of bio-inputs, such as application of plant growth-promoting inocula. However, the evaluation of the potential of bacterial isolates from soils with different time histories of agricultural use are still scarce, and methods for isolation and testing of multifunctional microorganisms need to be continuously innovated and improved. Thus, we used G. max bait plants to attract rhizobacteria from soils obtained from three areas with different time histories of soybean cultivation. We evaluated the influence of the management and characteristics of soils on the phosphate-solubilizing bacterial population. We then tested the multifunctional potential of the isolated rhizobacteria for calcium phosphate (CaHPO4) and iron phosphate (FePO4) solubilization, considering their potential as microbial inoculants in the future. The use of bait plants enabled the isolation of 139 phosphate solubilizing rhizobacteria, including four strains with multifunctional potential. The largest number of solubilizing bacteria was obtained from the interaction of bait plants with soil from an area with a history of soybean cultivation for thirty consecutive years. The high concentration of P, Fe, and K found in the soil were associated with this occurrence. In the in vitro tests, the pH values of the culture media had a moderate negative relationship with the amounts of P made available by the isolates, indicating that other processes besides the availability of organic acids, may underlie the solubilizing action of the isolates. The rhizobacteria SAF9 (Brevibacillus sp.), SAF11 (Brevibacillus sp.), BRC11 (Pseudomonas fluorescens), and SAC36 (Bacillus velezensis) stood out as multifunctional and are indicated within a perspective of obtaining bioinoculants to promote plant growth directly, indirectly, or synergistically, contributing to increase the range of bio-inputs for soybean cultivation and more sustainable agricultural practices.

Food Addiction and Consumption of Ultraprocessed Foods Among Undergraduate Nutrition and Dietetics Students

The aim of this study was to determine food addiction and consumption of ultraprocessed foods among undergraduate nutrition and dietetics students according to academic year. A total of 238 students participated in this cross-sectional study. The ultraprocessed food consumption frequency was assessed and the Yale Food Addiction Scale was applied. The overall prevalence of food addiction was 10.5%. The mean symptom count for food addiction was lower in the fourth year than in the first and second years (P = .002). The frequency of processed meat (r = −0.441, P &lt; .001) and donut consumption (r = −0.309, P &lt; .001) showed a moderate negative linear relationship with the increase in academic years.

Estimates of PM2.5 Concentration Based on Aerosol Optical Thickness Data Using Ensemble Learning with Support Vector Machine and Decision Tree

Air pollution, particularly fine particulate matter with a diameter of 2.5 micrometers or less (PM2.5), is a significant public health concern in many regions worldwide, including the northeastern region of Thailand. This study investigates the correlation between PM2.5 concentrations and meteorological spatial datasets such as surface relative humidity (SRH), surface wind speed (SPD), visibility (Vis), surface temperature (ST), and aerosol optical thickness (AOT) in the region. GIS techniques and the inverse distance weighting technique were used to create spatial maps of the meteorological datasets and ground station PM2.5 measurements. Pearson correlation analysis was performed to examine the relationship between PM2.5 and the meteorological datasets. Decision tree and support vector machine (SVM) algorithms were employed to estimate PM2.5 concentrations based on the spatial datasets. The results showed that Vis and ST have a moderate positive linear relationship with PM2.5, while AOT has a moderate negative linear relationship. SRH and SPD have weak relationships with PM2.5. The decision tree and SVM algorithms demonstrated a strong positive correlation between estimated and measured PM2.5 concentrations. The study shows that machine learning algorithms can be effective tools for estimating PM2.5 concentration based on AOT data, and feature selection can improve model performance. Ensemble learning could be employed to further improve model performance, particularly in regions with high spatial variability. Overall, the study provides a promising approach for estimating PM2.5 concentration using machine learning algorithms and AOT data.

Psychosocial factors affecting the quality of life of parents who have children with home mechanical ventilation

AbstractIntroductionMost children with medical complexity have to live with home mechanical ventilation (HMV). Undertaking the care of a child with HMV creates a psychosocial burden on parents. This study investigated the impact of selected potential determinants on the quality of life of parents who have children with HMV.MethodsA cross‐sectional survey study was conducted using a structured questionnaire to determine the sociodemographic characteristics of the parents. The World Health Organization Quality of Life Assessment‐Brief version, the Beck Depression Inventory (BDI), and the Multidimensional Scale of Perceived Social Support were applied.ResultsA total of 35 participants responded to the questionnaires. Paired data from mothers and fathers were obtained from 12 families. A moderately significant positive correlation was found between the perceived social support levels of the parents and all domains of the quality of life scale (for the physical domain: r = .455, p = .006; for the psychological domain: r = .549, p = .001; for the social domain: r = .726, p = .000; and for the environment domain: r = .442, p = .008). A moderate negative relationship was found between parents’ perceived social support levels and BDI scores (r = −.557, p = .001). The multivariate regression analysis determined that being a mother, quitting a job to become a caregiver, being the only caregiver at home, and having a neurological/neuromuscular disease as the primary disease of the child were associated with lower scores in more than one quality of life domain.ConclusionOur results emphasize that appropriate social support is important for improving the quality of life scores of parents of children with HMV.

Synaptic density is correlated with Aβ plaques and neurofibrillary tau tangles across the clinical and biologic Alzheimer’s disease continuum

AbstractBackgroundThe extent to which amyloid‐β burden and neurofibrillary tau tangle burden are associated with synaptic degeneration in vivo is not well known. PET imaging was used to examine the cross‐sectional relationship between neurofibrillary tau tangle burden and amyloid‐β plaque burden with synaptic density among individuals who spanned the clinical and biologic Alzheimer’s disease continuum.MethodParticipants were recruited from the Wisconsin Alzheimer’s Disease Research Center and the Wisconsin Registry for Alzheimer’s Prevention study. N = 64 participants were included in the analysis based on completed cognitive testing, structural MR and PET imaging using [11C]PiB DVR for amyloid burden, [18F]MK‐6240 SUVR for regional neurofibrillary tau burden, and [11C]UCB‐J DVR for regional synaptic density burden analysis. Amyloid burden was indexed as a global [11C]PiB DVR representing the mean of brain regions that typically accumulate amyloid. UCB‐J DVR and MK‐6240 SUVR regions of interest were selected based on the histopathological staging of tau pathology in Alzheimer’s disease with a focus on regions of tau pathology described by earlier and later Braak stages. The first composite region of interest (ROI1) comprised the hippocampus and entorhinal cortex, and the second (ROI2) comprised the amygdala, fusiform, lingual gyrus, and the inferior temporal gyrus. Linear correlations (Pearson’s r) tested the relationship between UCB‐J DVR and PiB DVR, as well as UCB‐J DVR and MK‐6240 SUVR.ResultGlobal [11C]PiB DVR showed a moderate negative relationship with UCB‐J DVR in ROI1 (r = ‐0.42, p = 0.0006) and a weak relationship with UCB‐J DVR in ROI2 (r = ‐0.33, p = 009). [18F]MK‐6240 SUVR and UCB‐J DVR were negatively correlated in ROI1 (r = ‐0.44, p = 0.0003) and in ROI2 (r = ‐0.42, p = 0.005).ConclusionBoth amyloid burden and tau pathology were associated with lower synaptic density. Tau and synaptic density appeared to show moderate correlations among brain regions involved in both earlier and more advanced tau pathology, whereas amyloid burden appeared to be more strongly related to synaptic density in brain regions where more advanced disease is typically observed.

Synaptic density is correlated with Aβ plaques and neurofibrillary tau tangles across the clinical and biologic Alzheimer’s disease continuum

AbstractBackgroundThe extent to which amyloid‐ß burden and neurofibrillary tau tangle burden are associated with synaptic degeneration in vivo is not well known. PET imaging was used to examine the cross‐sectional relationship between neurofibrillary tau tangle burden and amyloid‐ß plaque burden with synaptic density among individuals who spanned the clinical and biologic Alzheimer’s disease continuum.MethodParticipants were recruited from the Wisconsin Alzheimer’s Disease Research Center and the Wisconsin Registry for Alzheimer’s Prevention study. N = 64 participants were included in the analysis based on completed cognitive testing, structural MR and PET imaging using [11C]PiB DVR for amyloid burden, [18F]MK‐6240 SUVR for regional neurofibrillary tau burden, and [11C]UCB‐J DVR for regional synaptic density burden analysis. Amyloid burden was indexed as a global [11C]PiB DVR representing the mean of brain regions that typically accumulate amyloid. UCB‐J DVR and MK‐6240 SUVR regions of interest were selected based on the histopathological staging of tau pathology in Alzheimer’s disease with a focus on regions of tau pathology described by earlier and later Braak stages. The first composite region of interest (ROI1) comprised the hippocampus and entorhinal cortex, and the second (ROI2) comprised the amygdala, fusiform, lingual gyrus, and the inferior temporal gyrus. Linear correlations (Pearson’s r) tested the relationship between UCB‐J DVR and PiB DVR, as well as UCB‐J DVR and MK‐6240 SUVR.ResultGlobal [11C]PiB DVR showed a moderate negative relationship with UCB‐J DVR in ROI1 (r = ‐0.42, p = 0.0006) and a weak relationship with UCB‐J DVR in ROI2 (r = ‐0.33, p = 009). [18F]MK‐6240 SUVR and UCB‐J DVR were negatively correlated in ROI1 (r = ‐0.44, p = 0.0003) and in ROI2 (r = ‐0.42, p = 0.005).ConclusionBoth amyloid burden and tau pathology were associated with lower synaptic density. Tau and synaptic density appeared to show moderate correlations among brain regions involved in both earlier and more advanced tau pathology, whereas amyloid burden appeared to be more strongly related to synaptic density in brain regions where more advanced disease is typically observed.

Does medullary diameter to stem width ratio and stem length affect outcomes of revision total knee arthroplasties? A case series.

This study aimed to investigate the relationship between the ratio of stem size to intramedullary canal diameter, stem length, and functional outcome in revision total knee arthroplasty (RTKA) procedures, which remains largely unexplored in the current literature. A single surgeon series of RTKA procedures performed between October 2014 and November 2022 were included in this case series, and data were analyzed retrospectively. A total of 32 patients (27 females, 5 males; mean age: 73.2±8.1 years; range, 52 to 88 years) were identified, with a minimum follow-up period of five months and a maximum of eight years. Filtering the patients based on >24 month follow-up, we were left with 13 patients aged between 65 and 88 (mean 74.9±6.9) years. The latest X-rays of patients were analyzed, and the ratio of intramedullary canal diameter to stem width was calculated for both femur and tibia in both anteroposterior and lateral planes. Household income, preoperative C-reactive protein, erythrocyte sedimentation rate, comorbidities, body mass index, and implant dimensions were also recorded. Postoperative Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Short Form-12 (SF-12) scores, and range of motion (ROM) measurements were used to evaluate functional outcome. A moderate negative relationship between the tibial canal fill ratio (CFR) in anteroposterior views and ROM of the patients was noted. Additionally, a significant positive correlation was found between SF-12 physical score and CFR in lateral view. A moderate level of correlation between femoral CFR in anteroposterior views was also established. Due to insufficient data, joint ROM data did not show normal distribution. Therefore, a cutoff value indicating the relationship between the stem size and knee ROM could not be calculated using receiver operating characteristic analysis. Multiple regression analysis did not yield significant results, suggesting that hypothesized predictor variables were not sufficient to predict the variation in functional scores. Otherwise, no clear statistical importance or correlation between functional scores, such as WOMAC or SF-12, and CFR was found. In conclusion, the findings suggest that other factors, such as other patient characteristics, surgical techniques, or implant designs, may have a more substantial impact on the functional outcomes in RTKA patients.

Relationship between Personality and Academic Procrastination amongst Undergraduate Students in Selected Private Universities in Kuala Lumpur

This research is to investigate the relationship between personality and academic procrastination amongst undergraduate students in selected private Universities in Kuala Lumpur. In this research, the sample consisted of 150 undergraduate students from selected private universities in Kuala Lumpur, 106 female students and 44 male students. The first result for this present research showed that there is a significant relationship between personality and academic procrastination as three of the five personality domains are found to have a significant relationship with academic procrastination at 0.05 and 0.01 level of significance. The second result showed that there is a moderate significant negative relationship between conscientiousness and academic procrastination, r = .402, p &lt; .01. The third result showed that there is a weak significant positive relationship between neuroticism and academic procrastination, r = .244, p &lt; .01. The fourth result showed that there is a weak significant negative relationship between agreeableness and academic procrastination, r = -.161, p &lt; .05. The fifth result showed that there was a nonsignificant correlation of .030 (p = n.s.) between openness to experience and academic procrastination. The sixth result showed that there was a nonsignificant correlation of -.098 (p = n.s.) between extraversion and academic procrastination. The recommendations for future researchers are also suggested in this research which included the conduct of this research in different countries with respondents from different backgrounds.

Search for genetic markers for selection and breeding aimed at increasing birth weight of piglets

With the intensive increase in the fertility traits of sows, the problem of decreasing the weight of piglets at birth has arisen. In this connection, the search for genetic variants associated with the birth weight of piglets is of particular relevance and scientific significance. The aim of the work was to identify genetic variants associated with piglet weight at birth and test them to select optimal genetic markers for selection and breeding work to improve reproductive performance of pigs on the basis of full genomic genotyping data using the Fst method. The studies were conducted in 2020-2022 on Large White pigs (n=239) bred at CJSC Plemzavod-Yubileiny in the Tyumen Region. Genotyping was performed using GeneSeek® GGP Porcine HD Genomic Profiler v1 (Illumina Inc., USA). Genomic data were filtered according to the following parameters --geno 0.1, -mind 0.1, -maf 0.05, -hwe 1e-7, --indep-pairwise 50 5 0.8. To identify genomic regions associated with piglet birth weight, there was used Fst statistics comparing genetic variants in pigs between two groups with high and low indices. Those in which the Fst values exceeded the quantile level of 0.999 were considered significant variants. Student's test was used to evaluate the significance of the effects of variant genotypes on the birth weight and number of piglets at birth. The results showed that there was a moderate negative relationship (-0.351) between piglet birth weight and number of piglets at birth. 17 SNPs associated with birth weight of piglets were identified, 9 of which were located in the KIF13A, STK24, FDFT1, ADGRD1, STX2, TMEM132D, ENSSSCG00000054866, ENSSSCG00000058459 genes, as well as SNPs rs81450496, rs80887103 in intergenic regions have been identified as promising genetic markers for increase in birth weight of piglets. The results obtained can be used to create domestic breeding technologies that improve the efficiency of pig breeding.

Dexmedetomidine Withdrawal Syndrome in Children in the PICU: Systematic Review and Meta-Analysis.

To systematically review literature describing the clinical presentation, risk factors, and treatment for dexmedetomidine withdrawal in the PICU (PROSPERO: CRD42022307178). MEDLINE/PubMed, Cochrane, Web of Science, and Scopus databases were searched. Eligible studies were published from January 2000 to January 2022 and reported clinical data for patients younger than 21 years old following discontinuation of dexmedetomidine after greater than or equal to 24 hours of infusion. Abstracts identified during an initial search were screened and data were manually abstracted after full-text review of eligible articles. The Newcastle-Ottawa Scale was used to assess study quality. Summary statistics were provided and Spearman rank correlation coefficient was used to identify relationships between covariates and withdrawal signs. A weighted prevalence for each withdrawal sign was generated using a random-effects model. Twenty-three studies (22 of which were retrospective cohort studies) containing 28 distinct cohorts were included. Median cumulative dexmedetomidine exposure by dose was 105.95 μg/kg (range, 30-232.7 μg/kg), median dexmedetomidine infusion duration was 131.75 hours (range, 20.5-525.6 hr). Weighted estimates for proportion (95% CI) of subjects experiencing withdrawal signs across all cohorts were: hypertension 0.34 (range, 0.0-0.92), tachycardia 0.26 (range, 0.0-0.87), and agitation 0.26 (range, 0.09-0.77). Meta-analysis revealed no correlation between dexmedetomidine exposure variables and withdrawal signs. A moderate negative monotonic relationship existed between the proportion of patients who had undergone cardiac surgery and the proportion experiencing hypertension (correlation coefficient, -0.47; p = 0.048) and tachycardia (correlation coefficient, -0.57; p = 0.008), indicating that in cohorts with a higher proportion of patients who were postcardiac surgery, there were fewer occurrences of hypertension and or tachycardia. On review of the 2000-2022 literature, dexmedetomidine withdrawal may be characterized by tachycardia, hypertension, or agitation, particularly with higher cumulative doses or prolonged durations. Since most studies included in the review were retrospective, prospective studies are needed to further clarify risk factors, establish diagnostic criteria, and identify optimal management strategies.